Preparation of chiral pyrrole derivatives by the Paal-Knorr reaction

ArticleinChemistry of Heterocyclic Compounds 47(2):182-193 · May 2011with13 Reads
Impact Factor: 0.62 · DOI: 10.1007/s10593-011-0739-7


    A new approach has been developed for the synthesis of N-alkylpyrroles with a chiral substituent at the nitrogen atom by the
    Paal-Knorr reaction using esters of amino acids as the source of chirality.

    Keywords1,4-dicarbonyl compounds–2,5-dimethyl- and 5-aryl-2-methylpyrroles with a chiral substituent at the nitrogen atom–chiral pyrrole derivatives–iodine-catalyzed cyclization–Paal-Knorr method–Stetter reaction