Article

Role of Apoptosis in disease

Dipartimento di Scienze Biomediche, Universita' "G. d'Annunzio" Chieti-Pescara, Italy.
Aging (Impact Factor: 6.43). 05/2012; 4(5):330-49.
Source: PubMed

ABSTRACT

Since the initial description of apoptosis, a number of different forms of cell death have been described. In this review we will focus on classic caspase-dependent apoptosis and its variations that contribute to diseases. Over fifty years of research have clarified molecular mechanisms involved in apoptotic signaling as well and shown that alterations of these pathways lead to human diseases. Indeed both reduced and increased apoptosis can result in pathology. More recently these findings have led to the development of therapeutic approaches based on regulation of apoptosis, some of which are in clinical trials or have entered medical practice.

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    • "Aberrant activation of caspases has been implicated in a number of conditions, including autoimmunity, transplant rejection and heart failure (Ocker and Höpfner, 2012). Manipulating caspase signaling has a therapeutic benefit on diverse diseases, such as cardiovascular, autoimmune and infectious disease (Favaloro et al., 2012). "

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