Hydrogels for Biosensors

Chapter · February 2010with45 Reads
DOI: 10.1007/978-3-540-75645-3_6


    Hydrogels are valuable materials for use in biosensors. They can be used for immobilization as well as for creating protecting
    layers controlling diffusion and enhancing biocompatibility. Highly stable biosensors use hydrogels for entrapment of enzymes
    on microelectrodes. The stability of enzymes in hydrogel membranes for biosensors can be enhanced by choosing the right microenvironment
    using micro-hydrogels. The thermodynamic stability of the entrapped enzymes in micro-gels can be characterized via differential
    scanning calorimetry (nano-DSC). Hydrogel-based biosensors were characterized by nano-DSC showing that hydrogel membranes
    are excellent for creating long-term stable enzyme biosensors. Additionally, smart hydrogels can be used as stimuli responsive
    materials enabling sensing as well as actuating performance.

    KeywordsMulti-analyte biosensor–Microelectrode-array–Enzyme immobilization–Enzyme stability–Differential scanning calorimetry (DSC)–Chip-calorimeter