Hallucinations and comorbid renal tubular acidosis caused by topiramate in a patient with psychiatric history

ArticleinGeneral hospital psychiatry 35(2) · May 2012
Impact Factor: 2.61 · DOI: 10.1016/j.genhosppsych.2012.04.008 · Source: PubMed


    Few studies have shown that topiramate may induce psychiatric symptoms and metabolic disorders, respectively. Here, we reported a 13-year-old female who presented with topiramate-induced hallucinations and comorbid renal tubular acidosis. She had a history of psychiatric illness and had been taking the medication for 3 months without prior side effects. After the discontinuation of topiramate, she was treated with supplementary potassium and sodium bicarbonate. Subsequently, her psychiatric symptoms and biochemical findings improved. Recognition of drug-induced psychotic symptoms and renal tubular acidosis is important during concomitant topiramate therapy in psychiatric clinic.