The effects of dietary flavonoids on the regulation of redox inflammatory networks

Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy.
Frontiers in Bioscience (Impact Factor: 3.52). 01/2012; 17:2396-418.
Source: PubMed


Dietary flavonoids are a large family of polyphenols ubiquitously expressed in plants. Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells. This report will review current knowledge on the anti-inflammatory effects of flavonoids on immune cells focusing on their ability to modulate multiple redox-sensible pathways involved in inflammation.

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Available from: Fabio Galvano, Jan 09, 2014
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    • "Numerous studies have shown that both MAPKs and NF-κB signaling pathways are involved in activation of an inflammatory response [57], [58]. Thus, inhibition of the LPS-stimulated signal transduction cascades has been proposed as a promising target for the treatment of inflammation. "
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    • "There have been numerous studies demonstrating the health benefits of flavonoids, which are mostly known for their antioxidant and anti-inflammatory properties, as well as the benefits they provide for cardiovascular health (Alezandro et al. 2013; Izzi et al. 2012; Macedo et al. 2013; Perez- Vizcaino and Duarte 2010). Due to their immense diversity, they are divided into subgroups including flavonols, flavanols, flavones, flavanones, isoflavones, anthocyanidins and chalcones. "
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