Low-grade inflammation in young adults exposed to intrauterine hyperglycemia

Center for Pregnant Women with Diabetes, Department of Obstetrics, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark.
Diabetes research and clinical practice (Impact Factor: 2.54). 05/2012; 97(2):322-30. DOI: 10.1016/j.diabres.2012.04.023
Source: PubMed


To investigate associations between fetal exposure to intrauterine hyperglycemia and plasma concentrations of interleukin-6 (IL-6) and high sensitivity C-reactive protein (hs-CRP) in adult offspring.
We studied 597 offspring, aged 18-27 years, from four different groups concerning exposure to intrauterine hyperglycemia and genetic predisposition to type 2 diabetes (offspring of women with: gestational diabetes mellitus (GDM), risk factors for GDM but normal glucose tolerance, type 1 diabetes and women from the background population, respectively). The participants were characterized by fasting plasma levels of IL-6 and hs-CRP, a 75 g oral glucose tolerance test and anthropometric measurements.
No association between intrauterine exposure to hyperglycemia and levels of IL-6 and hs-CRP in the offspring was found. In contrast maternal overweight (body mass index ≥ 25 kg/m(2)) was positively associated with levels of both IL-6 and hs-CRP (p for both=0.003). Offspring who had already developed overweight or conditions of abnormal glucose tolerance were characterized by higher levels of IL-6 and hs-CRP compared with the remaining offspring (all p<0.007).
Maternal overweight but not exposure to intrauterine hyperglycemia was associated with low-grade inflammation in adult offspring.

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Available from: Louise Kelstrup, Jul 11, 2014