Bringing next-generation therapeutics to the clinic through synthetic biology

ArticleinCurrent opinion in chemical biology 16(3-4):355-61 · May 2012with22 Reads
Impact Factor: 6.81 · DOI: 10.1016/j.cbpa.2012.04.009 · Source: PubMed


    Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.