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Anti-inflamatory activity of fullerenol C60(OH)24 nano-particles in a model of acute inflammation in rats
Abstract and Figures
Water soluble fullerene (C60) derivative fullerenol C60(OH)24 nano-particles (FNP) are a promising candidate for many biomedical applications due to, besides other properties, strong free-radical scavenging and antioxidative potential. Using the carrageenan-induced rat footpad oedema test, the anti-inflammatory effect of FNP have been estimated in comparison with those of amifostine (AMI) and indomethacin (IND). FNP and IND, dissolved in dimethylsulfoxide, and AMI, dissolved in saline, were intraperitoneally injected to rats in a dose range 12.5 - 75 mg/kg, 3 - 10 mg/kg, and 50 - 300 mg/kg, respectively. The control groups were given corresponding vehicles. The drugs or vehicles were given 30 min before carrageenan injection. Footpad swelling was measured 3 hours after carrageenan application. Calculation of a per cent of inhibition derived through comparison with the control groups was done. Histopathological examination of the inflamed foot skin biopsies was also performed. FNP dose-dependently and significantly reduced the extent of footpad oedema, comparable to that of IND and significantly better than AMI; their ED50 values (in μmol/kg) were: 35.36, 32.12 and 871.0, respectively. Histopathological examination confirmed these results. The largest therapeutic index of FNP suggests their safety for potential use in humans. Our results support the hypothesis that FNP produce a strong acute anti-inflammatory activity.
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