Lambert-Eaton myasthenic syndrome following H1N1-influenza vaccination - a case report

Department of Neurology, Oulu University Hospital, Oulu, Finland.
Acta Neurologica Scandinavica (Impact Factor: 2.4). 05/2012; 126(5):e25-8. DOI: 10.1111/j.1600-0404.2012.01675.x
Source: PubMed


The outbreak of influenza A (H1N1) pandemic during the year 2009 led to the development of several vaccinations against H1N1 virus. In Finland, 2.6 million citizens were vaccinated during pandemic 2009 - 2010 with adjuvanted influenza vaccine, Pandemrix(®) .
In this case report, we describe a patient with non-paraneoplastic Lambert-Eaton myasthenic syndrome following Pandemrix(®) vaccination.
Development of various autoimmune diseases in genetically predisposed subjects following exposure to certain environmental factors, including vaccinations, is a well-known entity. Clinicians should be aware of the possibility of the induction of autoimmune diseases following vaccinations and actively ask the relevant clinical history in a newly diagnosed patient with an autoimmune disorder.

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