Neurogenic Hypertension and Elevated Vertebrobasilar Arterial Resistance: Is There a Causative Link?

ArticleinCurrent Hypertension Reports 14(3):261-9 · May 2012with16 Reads
Impact Factor: 3.44 · DOI: 10.1007/s11906-012-0267-6 · Source: PubMed


    There is evidence of sympathetic overdrive in a significant proportion of patients with essential hypertension and an animal model of the condition, the spontaneously hypertensive rat (SHR). The reasons for this remain elusive. However, there is also evidence of narrowing of the arteries supplying the brainstem in the SHR and hypertensive humans. In this review, we discuss the possible role of brainstem hypoperfusion in driving increased sympathetic activity and hypertension.