Thioether Crosslinkages Created by a Radical SAM Enzyme

ArticleinChemBioChem 13(8):1097-9 · May 2012with26 Reads
Impact Factor: 3.09 · DOI: 10.1002/cbic.201200196 · Source: PubMed


    Unusually versatile: While the β-carbon thioether linkage in lantibiotics has long been appreciated and is relatively well characterized, a recent publication shows that the unusual sulfur-to-α-carbon thioether crosslinks in subtilosin A are produced by a radical SAM enzyme, AlbA, that contains two [4 Fe-4 S] clusters, thus highlighting the versatility of post-translational modifications in natural product biosynthesis.