Very late thrombosis of a paclitaxel-eluting stent after 72 months in a patient on dual anti-platelet therapy

Institute of Cardio-Vascular Diseases, Madras Medical Mission, Chennai, India.
Cardiovascular journal of Africa 04/2012; 23(3):e9-11. DOI: 10.5830/CVJA-2011-022
Source: PubMed


Very late thrombosis continues to be a major cause of concern in the era of drug-eluting stents. The duration of vulnerability to this complication remains undefined. A 62-year-old diabetic male underwent primary percutaneous coronary intervention with a Taxus Express stent (Boston Scientific, Natick, Mass) implantation in 2003 for anterior wall myocardial infarction (AWMI). The patient was on dual anti-platelet treatment. He was asymptomatic and his stress test was negative in 2008. After 72 months, the patient was admitted with acute AWMI resulting from stent thrombosis, which was treated successfully. This case underscores the importance of realising that very late stent thrombosis may occur when patients present with angina symptoms.

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Available from: Mullasari Ajit Sankardas, Oct 24, 2015
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    ABSTRACT: While animal models are widely used to investigate the development of restenosis in blood vessels following an intervention, computational models offer another means for investigating this phenomenon. A computational model of the response of a treated vessel would allow investigators to assess the effects of altering certain vessel- and stent-related variables. The authors aimed to develop a novel computational model of restenosis development following an angioplasty and bare-metal stent implantation in an atherosclerotic vessel using agent-based modeling techniques. The presented model is intended to demonstrate the body’s response to the intervention and to explore how different vessel geometries or stent arrangements may affect restenosis development.
    Full-text · Article · Apr 2014 · PLoS ONE