Nutrient intake and plasma -amyloid

Taub Institute for Research in Alzheimer’s Disease and the Aging Brain, Columbia University, New York, NY, USA.
Neurology (Impact Factor: 8.29). 05/2012; 78(23):1832-40. DOI: 10.1212/WNL.0b013e318258f7c2
Source: PubMed


The widely reported associations between various nutrients and cognition may occur through many biologic pathways including those of β-amyloid (Aβ). However, little is known about the possible associations of dietary factors with plasma Aβ40 or Aβ42. The aim of the current study was to evaluate the association between nutrient intake and plasma Aβ levels.
In this cross-sectional study, plasma Aβ40 and Aβ42 and dietary data were obtained from 1,219 cognitively healthy elderly (age >65 years), who were participants in a community-based multiethnic cohort. Information on dietary intake was obtained 1.2 years, on average, before Aβ assay. The associations of plasma Aβ40 and Aβ42 levels and dietary intake of 10 nutrients were examined using linear regression models, adjusted for age, gender, ethnicity, education, caloric intake, apolipoprotein E genotype, and recruitment wave. Nutrients examined included saturated fatty acid, monounsaturated fatty acid, ω-3 polyunsaturated fatty acid (PUFA), ω-6 PUFA, vitamin E, vitamin C, β-carotene, vitamin B(12), folate, and vitamin D.
In unadjusted models that simultaneously included all nutrients, higher intake of ω-3 PUFA was associated with lower levels of Aβ40 (β = -24.7, p < 0.001) and lower levels of Aβ42 (β = -12.3, p < 0.001). In adjusted models, ω-3 PUFA remained a strong predictor of Aβ42 (β = -7.31, p = 0.02), whereas its association with Aβ40 was attenuated (β = -11.96, p = 0.06). Other nutrients were not associated with plasma Aβ levels.
Our data suggest that higher dietary intake of ω-3 PUFA is associated with lower plasma levels of Aβ42, a profile linked with reduced risk of incident AD and slower cognitive decline in our cohort.

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    • "Vascular risk factors including cholesterol and glycated hemoglobin (Hb A1C) are associated with higher concentrations of Ab 1-42 [16]. A recent report has suggested that higher dietary intakes of u3 polyunsaturated fatty acids were associated with lower plasma concentrations of Ab 1- 42 in cognitively healthy elderly subjects [17]. It has been hypothesized that a high plasma amyloid level was associated with mortality. "
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    ABSTRACT: Background We evaluated if plasma β-amyloid (Aβ) levels were associated with mortality risks in a subsample of the French Three-City (3C) prospective cohort study. Methods Analyses were based on 1254 participants randomly selected from the initial 3C cohort stratified by center, sex, and age in the context of a nested case-cohort study to investigate biological variables. Associations between plasma Aβ and mortality were assessed with the Cox regression model with delayed entry including various potential confounding factors and testing possible mediators. Results A relationship between high plasma Aβ1-40 concentrations and risk of mortality (hazards ratio, 1.15; 95% confidence interval, 1.01–1.31, P = .03) was unveiled independently of age, educational level, vascular risk factors, diet, physical activity, cognitive impairment, or frailty status. It was only modified when we included cystatin C levels. Conclusions Further investigations are needed to determine precisely the pathophysiological roles of plasma Aβ1-40 and cystatin C and before envisioning any future clinical applications.
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    • "Vitamin D might have little association with Aβ mechanisms and its potential association with AD might involve other pathways, such as antioxidative, vascular, anti-inflammatory, or metabolic pathways [78]. Genetic studies have provided the opportunity to determine that vitamin D is associated with AD risk [79, 80]. "
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    Full-text · Article · Jun 2013
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    • "In a cross-sectional study on the association between the ingestion of several nutrients and Aβ40 and Aβ42 plasma levels in a healthy elderly population (above age 65), Gu et al9 verified that the highest omega-3 intake level was associated with lower Aβ40 and Aβ42 concentrations, even after adjusting for age, gender, ethnicity, educational level, caloric intake, ApoE genotype, and recruiting period. "
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    Full-text · Article · May 2013 · Clinical Interventions in Aging
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