A Method of Moments Estimator for Random Effect Multivariate Meta-Analysis

ArticleinBiometrics 68(4) · May 2012with30 Reads
DOI: 10.1111/j.1541-0420.2012.01761.x · Source: PubMed
Meta-analysis is a powerful approach to combine evidence from multiple studies to make inference about one or more parameters of interest, such as regression coefficients. The validity of the fixed effect model meta-analysis depends on the underlying assumption that all studies in the meta-analysis share the same effect size. In the presence of heterogeneity, the fixed effect model incorrectly ignores the between-study variance and may yield false positive results. The random effect model takes into account both within-study and between-study variances. It is more conservative than the fixed effect model and should be favored in the presence of heterogeneity. In this paper, we develop a noniterative method of moments estimator for the between-study covariance matrix in the random effect model multivariate meta-analysis. To our knowledge, it is the first such method of moments estimator in the matrix form. We show that our estimator is a multivariate extension of DerSimonian and Laird's univariate method of moments estimator, and it is invariant to linear transformations. In the simulation study, our method performs well when compared to existing random effect model multivariate meta-analysis approaches. We also apply our method in the analysis of a real data example.
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    • "A Z test (Chen et al., 2012) was carried out to assess the significance of the overall effect size and forest plots were used to display the values of OR at 95%CIs between patient and control groups. Heterogeneity was assessed by the Cochran's Q-statistic (Chen et al., 2012), with P < 0.05 indicating the existence of heterogeneity. For quantification of the degree of heterogeneity, the I-squared (I 2 ) statistic (Peters et al., 2006) was calculated ranging from 0 to 100% (0%, no heterogeneity; 100%, maximal heterogeneity). "
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    • "Correlations between APOA5 and APOC3 SNPs and risk of CHD were estimated by the calculation of odds ratios (ORs) and 95% confidence intervals (95%CIs). A Z-test was employed to detect the significance of overall effect size (Chen et al., 2012), and forest plots were generated to display OR values and 95%CIs between case and control groups. Heterogeneity among studies was evaluated using Cochran's Q-statistic (P < 0.05 was considered to signify evident heterogeneity) and the I 2 test, which measures the percentage of total variation across studies, ranging from 0 to 100% (Peters et al., 2006; Jackson et al., 2012). "
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