Choriocarcinoma of the lung: Report of a case

Department of Cardiovascular and Thoracic Surgery, Nippon Medical School, Chiba Hokuso Hospital, 1715 Kamagari Inzai-shi, Chiba 270-1694, Japan.
General Thoracic and Cardiovascular Surgery 04/2012; 60(6):377-80. DOI: 10.1007/s11748-012-0009-3
Source: PubMed


In this report, a 27-year-old woman with a solitary pulmonary nodule is described. Because computed tomography-guided biopsy could not confirm the diagnosis, surgical treatment was performed by video-assisted thoracic surgery. Histological findings showed cytotrophoblasts and syncytiotrophoblasts, suggesting choriocarcinoma. However, there were no abnormal findings on gynecological examination, including ultrasonography, magnetic resonance imaging, and positron-emission tomography. Choriocarcinoma is a malignant neoplasm and can arise after a pregnancy, as a component of germ cell tumors, or in association with a poorly differentiated somatic carcinoma. Our patient, a young female with an antecedent gestation, has no recurrence after surgery. There were tumor emboli in pulmonary arteries and no component of primary lung carcinoma on histological examination. These findings indicate that the lesion was a metastasis of gestational choriocarcinoma. A rare case of a patient with metastatic gestational choriocarcinoma of a solitary pulmonary nodule without any uterine abnormality is presented.

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    • "Numerous studies on extragenital choriocarcinomas occurring in other organs, such as the lung (6), stomach (7) and colon (8), have previously been reported. To the best of our knowledge, the first description of a posterior mediastinal choriocarcinoma was by Yamashita et al (9) in 2002 of a 29-year-old male with posterior mediastinal choriocarcinoma. "
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    ABSTRACT: Primary choriocarcinoma of the posterior mediastinum is considered to be extremely rare, and the majority of these tumors occur in the gonads and uterus. The current study presents the case of a 40-year-old male who presented to the Department of Thoracic Surgery (Medical College of Yangzhou University, Yangzhou, China) with left chest pain for two months. Computed tomography of the chest showed a 4.9×5.2-cm mass in the posterior mediastinum and enlargement of the mediastinal lymph nodes. Resection of the tumor and upper lobe of the left lung was performed and the patient received combination chemotherapy with six courses of etoposide plus cisplatin. The patient recovered and was discharged. One year post surgery and chemotherapy, the patient was followed up and evidence of a recurrent tumor in the cerebrum was observed.
    Full-text · Article · Aug 2014 · Oncology letters
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    ABSTRACT: Non-gestational, extragonadal choriocarcinoma is a rare clinical entity. Herein, we report a 56 year old woman who presented with an incidental adrenal mass and was diagnosed with a non-gestational choriocarcinoma of the adrenal gland as the sole site of disease. To our knowledge, this is the first case of an ectopic primary adrenal choriocarcinoma. A metastasis from a primary tumor that completely regressed or that could not be identified is an alternate explanation. It should be recognized that choriocarcinoma can affect the adrenal gland and it should be considered as a rare cause for an adrenal incidentaloma. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.
    Full-text · Article · Dec 2014 · International Journal of Surgery Case Reports