Ameloblastic Fibrosarcoma of the Mandible: Treatment, Long-Term Follow-Up, and Subsequent Reconstruction of a Case

Formerly, Chief Resident, Department of Oral and Maxillofacial Surgery, School of Dentistry, Virginia Commonwealth University, Richmond, VA
Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons (Impact Factor: 1.43). 04/2012; 70(12). DOI: 10.1016/j.joms.2012.02.018
Source: PubMed
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    ABSTRACT: Objective: The aim of this study was to show the epidemiological features of 25 malignant odontogenic tumors (MOT) in Latin America. Materials and methods: We retrieved 25 cases of MOT out of 2142 odontogenic tumors, from four oral diagnostic centers in Latin America, and described the main clinical and pathological characteristics. Results: A total of 19 cases were carcinomas, including eight ameloblastic carcinomas, five primary intra-osseous squamous cell carcinomas, three clear cell odontogenic carcinomas and three ghost cell odontogenic carcinomas. All six sarcomas corresponded to ameloblastic fibrosarcoma. Thirteen cases occurred in men and 12 in women, age ranged from 7 to 77 years old, with a mean of 41.4 years. The average age of patients with carcinomas and sarcomas were 48.53 and 19 years old, respectively. Conclusion: As malignant odontogenic tumors are very rare, this series helps to better clarify their relative frequency, predominant subtypes, and clinical characteristics in Latin America.
    Full-text · Article · May 2013 · Oral Diseases
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    ABSTRACT: Ameloblastic fibrodentinoma (AFD) is a rare mixed odontogenic tumor, with biological behavior similar to ameloblastic fibroma (AF). These tumors are considered less invasive than solid ameloblastomas and have low tendency for recurrence. Sarcomatous transformation of AF is rare but well-recognized. Though of the same group, ameloblastic fibrosarcoma (AFS) developing after resection of AFD has not been reported in literature. We present a case of a well-encapsulated soft tissue AFS developing 8 years after aggressive treatment of previous recurrent AFD. The unusual biological behavior of AFD and the importance of long term follow-up of such patients are emphasized.
    No preview · Article · Dec 2013
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    ABSTRACT: This is an update on selected odontogenic malignancies. The article deals with aspects of recognized odontogenic carcinomas, odontogenic sarcoma and a yet unrecognized entity, sclerosing odontogenic carcinoma. Odontogenic malignancies are exceedingly rare, complicating a thorough understanding of the biologic behavior, reproducible standardized diagnostic criteria, appropriate classification and clinical management. Without the knowledge of the tumor's biologic behavior, adequate clinical management is difficult and patient outcomes uncertain. The histopathologic features are emphasized as well as the more recent biomarker findings. These recent advances may facilitate further understanding of this group of malignancies and provide useful stratification to guide patient management.
    No preview · Article · Nov 2014 · Head and Neck Pathology
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