The system epilepsies: A pathophysiological hypothesis

Department of Neurophysiology, IRCCS Foundation Neurological Institute Carlo Besta, Milan, Italy.
Epilepsia (Impact Factor: 4.57). 05/2012; 53(5):771-8. DOI: 10.1111/j.1528-1167.2012.03462.x
Source: PubMed


We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.

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Available from: Stefano Meletti
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