Prognostic significance of NANOG and KLF4 for breast cancer

Department of Surgery and Science, Graduate School of Research Into Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama, Japan, .
Breast Cancer (Impact Factor: 1.59). 04/2012; 21(1). DOI: 10.1007/s12282-012-0357-y
Source: PubMed


Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.
In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.
Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014).
Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.

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    • "It is the imbalance that determines the individual outcome (Figure 1). For example, NANOG expression is an indicator of poor prognosis stimulating the growth and metastasis of breast cancer cells, whereas KLF4 is a favorable prognostic indicator inhibiting these processes.55 2) The correlation between two factors is, at least in some cases, more significant than the overall expression of either. "
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