The Antifolates

ArticleinHematology/oncology clinics of North America 26(3):629-48, ix · June 2012with13 Reads
Impact Factor: 2.30 · DOI: 10.1016/j.hoc.2012.02.002 · Source: PubMed

    Abstract

    This article focuses on the cellular, biochemical, and molecular pharmacology of antifolates and how a basic understanding of the mechanism of action of methotrexate, its cytotoxic determinants, mechanisms of resistance, and transport into and out of cells has led to the development of a new generation of antifolates, a process that continues in the laboratory and in the clinics. New approaches to folate-based cancer chemotherapy are described based on the targeted delivery of drugs to malignant cells.