A simulator for the electro-chemical dynamics of the human cardiac cell

Conference Paper · October 2003with7 Reads
DOI: 10.1109/IEMBS.2003.1280486 · Source: IEEE Xplore
Conference: Engineering in Medicine and Biology Society, 2003. Proceedings of the 25th Annual International Conference of the IEEE, Volume: 3


    A simulator of the ionic dynamics in the human cardiomyocyte (E-C coupling process) is developed in this work using Matlab® v 6.5. It contains three different mathematical models, namely the models by Tang and Othmer, Luo and Rudy and Roche et al. Its user-friendly interface allows the comparison between the three models, the modification of the model parameters in correspondence with different cellular elements, and hence the testing of the sensibility of the E-C process to drugs and inhibitors. The simulator also features a graphics builder for the visualization of the results, and facilities to export data to other formats such as Excel®, or import experimental data from files. The simulator is compiled in a binary executable program and therefore is fully transportable.