NK-1 Receptor Antagonists: A New Generation of Anticancer Drugs

Research Laboratory on Neuropeptides, Virgen del Rocío University Hospital, Sevilla, Spain.
Mini Reviews in Medicinal Chemistry (Impact Factor: 2.9). 04/2012; 12(7):593-9. DOI: 10.2174/138955712800626692
Source: PubMed


After binding to the neurokinin-1 (NK-1) receptor, substance P (SP) induces tumor cell proliferation, angiogenesis, and the migration of tumor cells for invasion and metastasis. After binding to NK-1 receptors, NK-1 receptor antagonists inhibit tumor cell proliferation, angiogenesis and the migration of tumor cells. These antagonists are broad-spectrum antitumor drugs. In addition, in the host they display beneficial effects: anxiolytic, antiemetic, neuroprotector, nephroprotector, hepatoprotector, antiinflammatory and analgesic. In combination therapy with classic cytostatics, NK-1 receptor antagonists have synergic effects and minimize the side-effects of these classic drugs. Thus, NK-1 receptor antagonists could offer a new and promising generation of anticancer drugs.

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