Article

Cholesterol gallstones

Gastroenterology (Impact Factor: 16.72). 10/1978; 75(3):514-6.
Source: PubMed
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    ABSTRACT: Since introduction of oral contraceptive steroids a variety of physiologic-adaptive and toxic side effects have been reported. A review is given. The study reports also four cases of hepatic vein thrombosis (Budd-Chiari-Syndrome-Venoocclusive disease) and three cases of benign hepatic tumors (liver cell adenoma and focal nodular hyperplasia) in young women following 2- to 5-year treatment with oral contraceptive steroids.
    No preview · Article · Jan 1979 · The Science of Nature
  • [Show abstract] [Hide abstract]
    ABSTRACT: Since introduction of oral contraceptive steroids a variety of physiologic-adaptive and toxic side effects have been reported. -a review is given. The study reports also four cases of hepatic vein thrombosis (Budd-Chiari-Syndrome--Venoocclusive disease) and three cases of benign hepatic tumors (liver cell adenoma and focal nodular hyperplasia) in young women following 2- to 5-year treatment with oral contraceptive steroids.
    No preview · Article · Nov 1979 · The Science of Nature
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    ABSTRACT: The increased risk of cholelithiasis during intake of oral contraceptives may be due to estrogen-induced saturation of the bile with cholesterol. In a randomized, prospective, crossed-over double-blind study 20 healthy women after roentgenological exclusion of gall-stones received either 1.0 mg of norethindrone acetate and 50 microgram ethinyl estradiol daily - as usual in oral contraception - for 21 days with 7 days of placebo treatment in each cycle or one fifth of this hormone dose in form of a continuous daily medication. After a 4 month's treatment the medication form was crossed-over. At the beginning of the study, before the cross-over and after the study bile was collected by duodenal intubation after a 12-h fast and the lithogenic index as a measure for cholesterol saturation of the bile was determined. No correlation between the dose and the lithogenic index was demonstrated, neither in 15 women, who had used oral contraceptives before the study nor in five women without any previous hormonal contraceptives.
    No preview · Article · Mar 1982 · Klinische Wochenschrift
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