Drug Delivery System Using Nano-Magnetic Fluid
DOI: 10.1109/ICICIC.2008.237 Conference: Innovative Computing Information and Control, 2008. ICICIC '08. 3rd International Conference on
Nano-size magnetic magnetide is considered important for various medical applications. Dynamic motion of the magnetic particle is investigated in two essential models from a theoretical point of view. One is a drag model of the magnetic particle in an artery. The second is a pull model towards the surface of artery. Threshold conditions of external variables are obtained by dimensional analysis. On the basis of all these results, it is concluded that the movement of magnetic fluids can be controlled by external magnetic fields in blood vessels.
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ABSTRACT: Nanofluids, the fluid suspensions of nanomaterials, have shown many interesting properties, and the distinctive features offer unprecedented potential for many applications. This paper summarizes the recent progress on the study of nanofluids, such as the preparation methods, the evaluation methods for the stability of nanofluids, and the ways to enhance the stability for nanofluids, the stability mechanisms of nanofluids, and presents the broad range of current and future applications in various fields including energy and mechanical and biomedical fields. At last, the paper identifies the opportunities for future research.
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ABSTRACT: Atherosclerosis, or hardening of the arteries, is one of the major causes of death in humans. High accumulation of Low-Density Lipoprotein (LDL) macromolecules within the arterial wall plays a critical role in initiation and development of atherosclerotic plaques. This paper proposes a proportional drug-encapsulated nanoparticle (PDENP) that utilizes a simple piecewise-proportional controller to realize swarm feedback control of LDL concentration in the interior of the arterial wall. In contrast to the competing strategies on nanorobotics, PDENPs carry simpler hardware architecture in order to be more reasonably realized technologically as well as to penetrate the interior arterial wall. Furthermore, in contrast to the existing targeted DENPs that usually target the surface proteins of atherosclerotic plaque, the proposed PDENPs directly sense the LDL level in the arterial walls. Hence, they can diagnose abnormal LDL accumulation before plaque formation, prevent critical growth of atherosclerotic plaques, while considerably reducing the unwanted drug side effects in healthy tissue. Simulation results on a well-known mathematical model of the arterial wall demonstrate that the proposed approach successfully reduces the LDL level to a desired value in the arterial wall of a patient with very high LDL level. Also, the mass of the released drug by PDENPs in a healthy wall is 11 times less than its corresponding value in an unhealthy wall.
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