Article

Body weight changes and corresponding changes in pain and function in persons with symptomatic knee osteoarthritis: A cohort study

Virginia Commonwealth University, Department of Physical Therapy, PO Box 980224, Richmond, VA 23298-0224. .
Arthritis care & research 01/2013; 65(1). DOI: 10.1002/acr.21692
Source: PubMed

ABSTRACT

OBJECTIVE: To determine if a dose-response relationship exists between percentage body weight changes in persons with symptomatic knee osteoarthritis (OA) and self reported pain and function. METHODS: Data from persons in the Osteoarthritis Initiative (OAI) and the Multicenter Osteoarthritis (MOST) datasets (n=1,410) with symptomatic function limiting knee OA were studied. For the OAI, we used baseline and 3-year follow-up data while for the MOST, baseline and 30-month data were used. Key outcome variables were WOMAC Physical Function and Pain change scores. In addition to covariates, the predictor variable of interest was the extent of weight change over the study period and divided into 5 categories representing different percentages of body weight change. RESULTS: A significant dose-response relationship (p< 0.003) was found between the extent of percentage change in body weight and the extent of change in WOMAC Physical Function and WOMAC Pain. For example, persons who gained ≥10% of body weight had WOMAC Physical Function score changes of -5.4 (95%CI, -8.7, -2.00) points indicating worsening relative to the reference group of persons with weight changes of between <5% weight gain and <5% weight reduction. CONCLUSION: Our data suggest a dose-response relationship exists between changes in body weight and corresponding changes in pain and function. The threshold for this response gradient appears to be ≥10% body weight shifts. Weight changes of ≥10% have potential to lead to important changes in pain and function for patient groups as well as individual patients. © 2012 by the American College of Rheumatology.

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    • "Knee pain is the most common and disabling symptom of Osteoarthritis (OA) [1] [2]. This disease affects 1 in every 10 adults over 60 years in the United States and the rate of incidence is incrementing due to changes in lifestyle and life expectancy [3] [4] [5] [6] [7]. The prevalence and the symptomatic importance of pain in OA subjects make pain prediction a very important task for the management of OA patients. "
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    • "Weight loss relieves pain in obese OA patients, with a weight loss of at least 10 % providing significant pain reduction [48] . A recent study in individuals with symptomatic knee OA suggested a dose–response relationship between changes in body weight and corresponding changes in pain and physical function [49]. To date, no small animal models of obesity-induced OA have evaluated the effect of specific interventions on pain, but trials in overweight dogs confirm that exercise and weight loss may have a positive effect on pain and gait [50, 51]. "
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