Optimal approach to immunization in pediatric solid organ transplantation
Pediatric Infectious Diseases, Pediatric Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine at Case Western Reserve University, Cleveland, OH, USA Pediatric Infectious Diseases, Department of Pediatrics, Children's Hospital of Geneva, University Hospitals of Geneva, Geneva University of Geneva Medical School, Geneva, Switzerland E-mail: .Pediatric Transplantation (Impact Factor: 1.44). 04/2012; 16(7):680-3. DOI: 10.1111/j.1399-3046.2012.01689.x
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ABSTRACT: Solid organ and hematopoietic stem cell transplant recipients may be exposed to diseases which may be prevented through live attenuated virus vaccines (LAVV). Because of their immunosuppression, these diseases can lead to severe complications in transplant recipients. Despite increasing evidence regarding the safety and effectiveness of certain LAVV, these vaccines are still contraindicated for immunocompromised patients, such as transplant recipients. We review the available studies on LAVV, such as varicella zoster, measles-mumps-rubella, influenza, yellow fever, polio, and Japanese encephalitis vaccines in transplant patients. We discuss the current recommendations and the potential risks, as well as the expected benefits of LAVV immunization in this population.
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