Journal of Allergy 7
 P. J. Barnes, “Mediators of chronic obstructive pulmonary dis-
ease,” Cell and Molecular Biology, vol. 50, pp. OL627–OL637,
 P. Kirkham and I. Rahman, “Oxidative stress in asthma and
COPD: antioxidants as a therapeutic strategy,” Pharmacology
and Therapeutics, vol. 111, no. 2, pp. 476–479, 2006.
 G. Tsuji, M. Takahara, H. Uchi et al., “An environmental
contaminant, benzo(a)pyrene, induces oxidative stress-medi-
ated interleukin-8 production in human keratinocytes via
the aryl hydrocarbon receptor signaling pathway,” Journal of
Dermatological Science, vol. 62, pp. 42–49, 2011.
 J. M. Martinez, C. A. Afshari, P. R. Bushel, A. Masuda, T.
Takahashi,andN.J.Walker,“Diﬀerential toxicogenomic re-
sponses to 2,3,7,8-tetrachlorodibenzo-p-dioxin in malignant
and nonmalignant human airway epithelial cells,” Toxicolog i-
cal Sciences, vol. 69, no. 2, pp. 409–423, 2002.
 T. J. Standiford, S. L. Kunkel, M. A. Basha et al., “Interleukin-
8 gene expression by a pulmonary epithelial cell line. A
model for cy tokine networks in the lung,” Journal of Clinical
Investigation, vol. 86, no. 6, pp. 1945–1953, 1990.
 W. I. de Boer, H. S. Sharma, S. M. Baelemans, H. C.
Hooqsteden, B. N. Lambrecht, and G. J. Braunstahl, “Altered
expression of epithelial junctional proteins in atopic asthma:
possible role in inﬂammation,” Canadian Journal of Physiology
and Pharmacology, vol. 86, pp. 105–112, 2008.
 L. L. Collins, B. J. Lew, and B. P. Lawrence, “TCDD exposure
disrupts mammary epithelial cell diﬀerentiation and func-
tion,” Reproductive Toxicology, vol. 28, no. 1, pp. 11–17, 2009.
 C. Dietrich, D. Faust, M. Moskwa, A. Kunz, K. W. Bock, and F.
Oesch, “TCDD-dependent downregulation of gamma-catenin
in rat liver epithelial cells (WB-F344),” International Journal of
Cancer, vol. 103, no. 4, pp. 435–439, 2003.
remodeling and repair,” American Journal of Respiratory and
Critical Care Medicine, vol. 160, no. 3, pp. 1035–1042, 1999.
 Y. Sumi and Q. Hamid, “Airway remodeling in asthma,” Aller-
gology International, vol. 56, no. 4, pp. 341–348, 2007.
 J. Guo, M. Sartor, S. Karyala et al., “Expression of genes in
the TGF-beta signaling pathway is signiﬁcantly deregulated in
smooth muscle cells from aorta of aryl hydrocarbon receptor
knockout mice,” Toxicology and Applied P harmacolog y, vol.
194, no. 1, pp. 79–89, 2004.
 C. A. Martey, C. J. Baglole, T. A. Gasiewicz, P. J. Sime, and
R. P. Phipps, “The aryl hydrocarbon receptor is a regulator of
cigarette smoke induction of the cyclooxygenase and pros-
taglandin pathways in human lung ﬁbroblasts,” American
Journal of Physiology, vol. 289, no. 3, pp. L391–L399, 2005.
 M. Proﬁta, A. Sala, A. Bonanno et al., “Chronic obstructive
pulmonar y disease and neutrophil inﬁltration: role of cigarette
smoke and cyclooxygenase products,” American Journal of
Physiology, vol. 298, no. 2, pp. 261–269, 2010.
 H. Kita, C. R. Adolphason, and G. J. Gleich, “Biology of eos-
inophils,” in Middleton’s Allergy: Principles and Practice,N.F.
Anderson, J. W. Yunginger, W. W. Busse, B. S. Bochner, S.
T. Holgate, and F. E. Simons, Eds., pp. 305–332, Mosby,
Philadelphia, Pa, USA, 2003.
steroid hormone receptor superfamily by peroxisome prolif-
erators,” Nature, vol. 347, no. 6294, pp. 645–650, 1990.
 S. A. Kliewer, J. M. Lehmann, and T. M. Willson, “Orphan
nuclear receptors: shifting endocrinology into reverse,” Sci-
ence, vol. 284, no. 5415, pp. 757–760, 1999.
 R. Behshad, K. D. Cooper, and N. J. Korman, “A retrospective
case series review of the peroxisome proliferator-activated
receptor ligand rosiglitazone in the treatment of atopic der-
matitis,” Archives of Dermatology, vol. 144, no. 1, pp. 84–88,
 M. Spears, I. Donnelly, L. Jolly et al., “Bronchodilatory e
of the PPAR-gamma agonist rosiglitazone in smokers with
asthma,” Clinical Pharmacology and Therapeutic s, vol. 86, no.
1, pp. 49–53, 2009.
 S. Ueki, T. Adachi, J. Bourdeaux et al., “Expression of
PPARgamma in eosinophils and its functional role in survival
and chemotaxis,” Immunology Letters, vol. 86, no. 2, pp. 183–
 H. Hirasawa, T. Chiba, S. Ueki et al., “The synthetic
PPARgamma agonist troglitazone inhibits eotaxin-enhanced
eosinophil adhesion to ICAM-1-coated plates,” International
archives of allergy and immunology, vol. 146, supplement 1, pp.
 P. R. Hanlon, L. G. Ganem, Y. C. Cho, M. Yamamoto, and
C. R. Jefcoate, “AhR- and E RK-dependent pathways function
synergistically to mediate 2,3,7,8-tetrachlorodibenzo-p-dioxin
suppression of peroxisome proliferator-activated receptor-
gamma1 expression and subsequent adipocyte diﬀerentia-
tion,” Toxicology and Applied Pharmacology, vol. 189, no. 1, pp.
and C. R. Jefcoate, “Diﬀerentiation of pluripotent C3H10T1/2
cells rapidly elevates CYP1B1 through a novel process that
overcomes a loss of Ah receptor,” Archives of Biochemistry and
Biophysics, vol. 439, no. 2, pp. 139–153, 2005.
 M. Tauchi, A. Hida, T. Negishi et al., “Constitutive expression
of aryl hydrocarbon receptor in keratinocytes causes inﬂam-
matory skin lesions,” Molecular and Cellular Biology, vol. 25,
no. 21, pp. 9360–9368, 2005.
 R. S. Marcus, M. P. Holsapple, and N. E. Kaminski, “Lipo-
polysaccharide activation of murine splenocytes and splenic
B cells increased the expression of aryl hydrocarbon receptor
and aryl hydrocarbon receptor nuclear translocator,” Journal
of Pharmacology and Experimental Therapeutics, vol. 287, pp.
 H. Takenaka, K. Zhang, D. Diaz-Sanchez, A. Tsien, and A.
Saxon, “Enhanced human IgE production results from expo-
sure to the aromatic hydrocarbons from diesel exhaust: direct
eﬀects on B-cell IgE production,” Journal of Allergy and
Clinical Immunology, vol. 95, no. 1, pp. 103–115, 1995.
 E. Bettelli, T. Korn, M. Oukka, and V. K. Kuchroo, “Induction
and eﬀectorfunctionsofT(H)17cells,”Nature, vol. 453, no.
7198, pp. 1051–1057, 2008.
 F. J. Quintana, A. S. Basso, A. H. Iglesias et al., “Control of
T(reg) and T(H)17 cell diﬀerentiation by the aryl hydrocarbon
receptor,” Nature, vol. 453, no. 7191, pp. 65–71, 2008.
 L. A. Tesmer, S. K. Lundy, S. Sarkar, and D. A. Fox, “Th17 cells
in human disease,” Immunological Reviews, vol. 223, no. 1, pp.
 S. L. Gaﬀen, “An overview of IL-17 f unction and signaling,”
Cytokine, vol. 43, no. 3, pp. 402–407, 2008.
 K. Oboki, T. Ohno, H. Saito, and S. Nakae, “Th17 and allergy,”
Allergology International, vol. 57, no. 2, pp. 121–134, 2008.
and COPD,” Annual Review of Physiology, vol. 72, pp. 495–516,
 S. Schnyder-Candrian, D. Togbe, I. Couillin et al., “Interleu-
kin-17 is a negative regulator of established allergic asthma,”
Journal of Experimental Medicine, vol. 203, no. 12, pp. 2715–