Negative Feedback Loops: Nutrient Starvation Employs a New tr(IKK) to Inhibit PI3K

Department of Oncology, University of Alberta, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2.
Molecular cell (Impact Factor: 14.02). 03/2012; 45(6):705-6. DOI: 10.1016/j.molcel.2012.03.015
Source: PubMed


The PI3K pathway promotes insulin signaling to regulate metabolism and survival and is subject to multiple inhibitory feedback loops. In this issue of Molecular Cell,Comb et al. (2012) provide evidence indicating that the PI3K pathway is negatively regulated in a new way: by NFkB signaling during nutrient starvation.

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