Decidual Macrophages and Their Roles at the Maternal-Fetal Interface

Stem Cell and Regenerative Biology Department, Harvard University, Boston, MA 02115, USA.
The Yale journal of biology and medicine 03/2012; 85(1):105-18.
Source: PubMed


The semi-allogeneic fetus, whose genome consists of maternally and paternally inherited alleles, must coexist with an active maternal immune system during its 9 months in utero. Macrophages are the second most abundant immune cell at the maternal-fetal interface, although populations and functions for these populations remain ill defined. We have previously reported two distinct subsets of CD14(+) decidual macrophages found to be present in first trimester decidual tissue, 20 percent CD11c(HI) and 68 percent CD11c(LO). Interestingly, CD11c(HI) decidual macrophages express genes associated with lipid metabolism, inflammation, and antigen presentation function and specifically upregulate CD1 molecules. Conversely, CD11c(LO) decidual macrophages express genes associated with extracellular matrix formation, muscle regulation, and tissue growth. The large abundance of CD11c(HI) decidual macrophages and their ability to process antigens more efficiently than CD11c(LO) macrophages suggests that CD11c(HI) macrophages may be important antigen processing and presenting cells at the maternal-fetal interface, while CD11c(LO) macrophages may perform necessary homeostatic functions during placental construction. Thus, macrophage heterogeneity may be an important and necessary division of labor that leads to both an induction of maternal immune cell tolerance to fetal antigens as well as basic homeostatic functions in human pregnancy.

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Available from: Brandy Houser, Aug 18, 2014
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    • "Prenatal stress inducing an increase of inflammatory cytokines (i.e., TNF-α) has been suggested to modify the neonatal immune response through the expression of toll-like receptors (TLRs) and TLR-signaling pathways [146]. Although the interplay between the innate immune system and mood-related disorders is still obscure [145] [146], the study of interactions between the immune system, its active mediators [146] [147], and the brain [32] may reveal important pathophysiological mechanisms that are involved in the development of moodrelated disorders in pregnancy. "
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    • "Successful pregnancy also depends on the induction of maternal tolerance to foreign fetal tissues, and a distinct cytokine production profile which facilitates placental development and fetal growth (Salamonsen et al., 2007; Houser, 2012). In this regard, it has been shown that decidual cells around the early conceptus inhibit maternal immunity, so as to protect the allogeneic fetus from infiltrating cytotoxic T cells (CTLs). "
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