Epicardium-Derived Cardiac Mesenchymal Stem Cells Expanding the Outer Limit of Heart Repair
William Penn University, Filadelfia, Pennsylvania, United StatesCirculation Research (Impact Factor: 11.02). 03/2012; 110(7):904-6. DOI: 10.1161/RES.0b013e31825332a3
The epicardium is derived from the proepicardial organ, a source of multipotent progenitor cells. Epicardium contribution to the developing coronary vasculature and to cardiac interstitial cells has been established. Studies over the past several years have suggested that epicardium-derived cells can adopt cardiomyocyte and vascular smooth muscle fates and can contribute to cardiac repair when activated by injury.(1,2) Recently, Chong et al(3) have provided a detailed characterization of a population of epicardium-derived multipotent cardiac progenitor cells (cCFU-Fs). These cells, which do not arise from the bone marrow, neural crest, or myocardium, resemble mesenchymal stem cells (MSCs) and may participate in cardiac development, homeostasis, and repair.(3)
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