Bioactive Peptides from Marine Organisms: A Short Overview

Instituto de Quimica, Universidad Nacional Autonoma de Mexico, Circuito Exterior, Ciudad Universitaria, Mexico 04510, DF, Mexico.
Protein and Peptide Letters (Impact Factor: 1.07). 04/2012; 19(7):700-7. DOI: 10.2174/092986612800793208
Source: PubMed


Marine organisms are an immense source of new biologically active compounds. These compounds are unique because the aqueous environment requires a high demand of specific and potent bioactive molecules. Diverse peptides with a wide range of biological activities have been discovered, including antimicrobial, antitumoral, and antiviral activities and toxins amongst others. These proteins have been isolated from different phyla such as Porifera, Cnidaria, Nemertina, Crustacea, Mollusca, Echinodermata and Craniata. Purification techniques used to isolate these peptides include classical chromatographic methods such as gel filtration, ionic exchange and reverse-phase HPLC. Multiple in vivo and in vitro bioassays are coupled to the purification process to search for the biological activity of interest. The growing interest to study marine natural products results from the discovery of novel pharmacological tools including potent anticancer drugs now in clinical trials. This review presents examples of interesting peptides obtained from different marine organisms that have medical relevance. It also presents some of the common methods used to isolate and characterize them.

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Available from: Roberto Arreguin, Feb 27, 2014
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    • "Marine organisms have highly developed defense system in order to survive in the hostile conditions such as extreme temperatures, varied pressures (low or high), low energy and lack of sunlight. Thus, marine organisms offer a unique genetic pool that may possess the potential of treating several diseases including rare diseases or the ailments that are still considered incurable (Demunshi and Chugh, 2010; Lazcano-Pérez et al., 2012). This can be effectively deduced from the successfully FDA approved drugs (Table 1) such as Cytarabine (Ara-C), vidarabine (Ara-A), ziconotide, trabectedin, eribulin mesylate (Mayer et al., 2010; Martins et al., 2014). "
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    Full-text · Article · Jan 2015 · Global Ecology and Conservation
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    • "Marine organisms are an immense source of new biologically active compounds. One of the approaches for the effective acquisition of bioactive peptides from marine organisms is direct extraction, which is widely applied to improve and upgrade the functional and nutritional properties of proteins [18]. "
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    Full-text · Article · Jun 2013 · Marine Drugs
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    Full-text · Article · Oct 2012 · Chemico-biological interactions
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