- RESEARCH ARTICLE -
Antiulcer Potential of the Ethanolic Extract of
Aerva Persica Merrill Root in Rats
Neeru Vasudeva*, Payal Sethi, Surendra Kr. Sharma, Suresh Kumar,
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India
Available online Feb 10, 2012
Received: May 10, 2011
Accepted: Sep 9, 2011
The ethanol extract of the roots of Aerva persica (Burm f) Merrill (Amaranthaceae) was
investigated to determine its antiulcer and in vivo antioxidant activities in albino Wistar
rats. Ulcers were induced by ethanol and pylorus ligation. The extract was administered
at the dose of 200 mg/kg orally, p.o. for 15 consecutive days. The ulcer index of the ethanol
extract was found to be significantly reduced compared with control animals. The effect
was also assessed by determining the free acidity, pepsin activity, total carbohydrate
(TC), and protein content (PK) in control, standard, and test group animals. The in vivo
antioxidant activity was evaluated by determining the reduced glutathione level (GSH)
and malondialdehyde (MDA) level in the tissue homogenates. The results reveal the signif-
icant reduction in the level of malondialdehyde and the increase in the level of reduced
glutathione in the rats that received the ethanolic extract. Furthermore, histopathological
studies have shown that pretreatment with the ethanolic extract of the roots of A persica
reduces (100%) ethanol- and pylorus ligation-induced hemorrhagic necrosis in rats.
Peptic ulcer disease (PUD), which includes gastric and
duodenal ulcers, is the most prevalent gastrointestinal
disorder and requires a well-targeted therapeutic strategy.
The pathophysiology of PUD involves an imbalance between
offensive (acid, pepsin, and Helcobacter pylori) and
defensive factors (mucin, prostaglandin, bicarbonate,
nitric oxide, and growth factors) [1,2]. The most common
sites for ulcers are the stomach and the first few centi-
meters of the duodenum. Acute peptic ulcers involve
tissues down to the depth of the submucosa, and the lesions
may be single or multiple. Reasons for the development of
emotional disturbance, and postsurgical complications.
Chronic peptic ulcers penetrate through the epithelial and
* Corresponding author. Department of Pharmaceutical Sciences, Guru Jambeshwar University of Science and Technology, Hisar, Haryana-
Copyright ª 2012, International Pharmacopuncture Institute
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Journal of Acupuncture and Meridian Studies
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J Acupunct Meridian Stud 2012;5(2):80e86
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