Effects of phencyclidine on [3HJcate-cholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain

ArticleinBiochemical Pharmacology 26(15):1435-1439 · September 1977with1 Read
Impact Factor: 5.01 · DOI: 10.1016/0006-2952(77)90370-7


    Phencyclidine inhibited uptake in vitro of [3H]norepinephrine (ic50 0.52 μM), [3H]dopamine (ic50 0.73 μM) and [3H]serotonin (ic50 0.80 μM) in crude synaptosomal preparations from rat brain through a competitive mechanism. Phencyclidine was fairly similar in potency to d-amphetamine and methylphenidate in inhibiting catecholamine uptake but was 8 times more potent than d-amphetamine and 34 times more potent than methylphenidate in inhibiting [3H]serotonin uptake.