Article

Neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rats and mice

Ahmadu Bello University, Заря, Kaduna, Nigeria
Journal of Ethnopharmacology (Impact Factor: 3). 02/2005; 97(1):53-57. DOI: 10.1016/j.jep.2004.10.003

ABSTRACT

The present study evaluated the neuropharmacological effects of the aqueous extract of Nauclea latifolia root bark in rodents. Effects on the spontaneous motor activity (SMA), exploratory behaviour, pentobarbital sleeping time, apomorphine-induced stereotypic behaviour and motor coordination (rota-rod performance) were investigated. The extract (50–200 mg/kg p.o.) significantly (P < 0.05) decreased the SMA and exploratory behaviour in mice and prolonged pentobarbital sleeping time in rats dose-dependently. The extract also remarkably attenuated the intensity of apomorphine-induced stereotypy dose-dependently in mice, but had no effect on motor coordination as determined by the performance on rota-rod. These results indicate the presence of psychoactive substances in the aqueous extract of the root bark of Nauclea latifolia.

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Available from: Bulus Adzu, Feb 25, 2014
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    • "C'est une plante médicinale reconnue dans la pharmacopée traditionnelle. Elle présente des intérêts thérapeutiques qui ont fait l'objet de nombreux travaux (Amos et al., 2005 ; Iwueke et Nwodo, 2008 ; Yesufu et al., 2010; Boumendjel et al., 2013). L'utilisation de ses racines contre les maux de ventre constitue sa première utilisation dans le Sud-Ouest du Burkina Faso (Kaboré et al., 2014). "
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    • "and staying on the same spot (5). The stereotypic behavior was rated after each minute and mean of 15 min period was calculated and recorded (Amos et al. 2005; Erbas and Taskiran 2014). Assessment of stereotyped behavior was performed by two observers blind to the study groups. "
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