This research studies some of the psychometric properties of the Self-Regulation Inventory (SRI), a questionnaire designed by Grossarth-Maticek and Eysenck (1995) in order to assess coping behaviours related to health. The relationships between the SRI and basic dimensions of personality have also been investigated. A sample of 559 participants, 182 men and 377 women, answered both the SRI and the Eysenck Personality Questionnaire-Revised (EPQ-R). Our results showed that a five-factor solution of the SRI items appeared as the most robust internal structure for this instrument: positive actions, controllability, expression of feelings and needs, assertiveness, and well-being seeking. These five primary factors were clearly interrelated and a second-order factor analysis revealed a general self-regulation factor. Both the internal consistency and the temporal stability reliabilities of the SRI were adequate. In relation to personality, self-regulation was associated with emotional stability (low N) and extraversion and, to a lesser degree, with impulse control (low P).