Ram semen prostaglandin concentration and its effect on fertility.

Journal of Animal Science (Impact Factor: 2.11). 07/1977; 44(6):1050-4.
Source: PubMed

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    • "Prostaglandins, when activated by interaction with appropriate receptors, are known to bring about changes in the concentrations of second messengers such as cAMP, Ca 2þ and/or intracellular ions like K þ [17]. The presence of prostaglandin has been clearly demonstrated in ejaculates from the ram and the bull [18] [19], however, in boar semen prostaglandins have been low with average concentrations of both PGF 2a and PGE 2 usually less than 0.5 ng/ml [20] [21]. "
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    ABSTRACT: Addition of prostaglandin F2alpha (PGF2alpha) to extended boar semen has been shown to slightly increase reproductive parameters in sows such as the conception rate and the total number of piglets born alive. The mechanisms by which PGF2alpha affect these parameters have not yet been elucidated, but it is possible that the sperm transport after insemination is increased. This study investigated whether the sperm motility from 20 Piétrain boars improved when PGF2alpha (Dinolytic; 5 mg PGF2alpha/ml) was added to diluted semen. Different amounts of PGF2alpha (0, 0.5, 1 and 2 ml/100 ml) were tested and the motility was evaluated immediately after addition of PGF2alpha, after 30 min, 2 h, and 24 h. Two computer-assisted semen analysis (CASA) systems, namely the Sperm Quality Analyzer (SQA-IIC) and the Hamilton Thorne (HTR Ceros 12.1) were used to assess the motility parameters. With the SQA-IIC, sperm motility index values of the treated groups were only slightly higher (P>0.05) compared to the negative control group. The different motility parameters measured with the HTR Ceros 12.1 were similar between the treatment groups, except for beat cross frequency, which was higher in the control group (1.5-5%; P<0.001). This study documented that the addition of 2.5, 5 or 10 mg PGF2alpha to 100 ml diluted boar sperm does not increase any sperm motility parameter. Further research is necessary to elucidate mechanisms by which PGF2alpha in diluted semen may improve the reproductive performance in swine farms.
    Full-text · Article · Nov 2003 · Theriogenology
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    • "Although several investigators have investigated steroid hormone concentration in bull whole semen and seminal plasma [6] [7] [8], the levels of PGE in the seminal plasma have not been reported for the bull or the ram. The concentrations of prostaglandins, testosterone and estrogen in the semen have been suggested as parameters for infertility in man [9] [10] [11] [12] and ram [13]. Two important factors which influence the testicular hormonal production are cryptorchidism and season. "
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    ABSTRACT: Ram and bull seminal plasma, respectively, contain 0.5-20 microg PGE/ml and 5-10 ng PGE/ml. To demonstrate that PGE concentrations in the seminal plasma are related to sperm quality and could be affected by hormonal stimulation in vivo, four rams were injected with 500 IU hCG, in and out of season. The rams responded 1 week after hCG with a 1.5- to 4-fold increase in seminal plasma PGE. The PGE peak was temporally separate from the hCG-induced rise in seminal plasma testosterone which was observed after 1 day. Using a simulated cryptochid ram, peaks in seminal fluid PGE were found to be associated with increased sperm velocity and sperm counts. In bulls, PGE concentrations in the seminal plasma of good bulls were significantly higher than that found in poor and cryptorchid bulls.
    Full-text · Article · Feb 2003 · Prostaglandins & other lipid mediators
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    • "Edquist et al. (1975) and Gustafsson et al. (1977) added PGE1 or PGF2a to the inseminate or injected PGFza at the time of insemination of ewes and recovered more sperm from the oviducts of treated than untreated ewes 16 or 24 hr after insemination. Dimov and Georgiev (1977) added PGE2 and PGF2a to the inseminate and increased the lambing rate of ewes by about 15%. Although results have been somewhat inconsistent, apparently one or more of the prostaglandins can sometimes improve sperm transport in the female reproductive tract. "

    Preview · Article · Aug 1979 · Journal of Animal Science
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