In creating a psychologically supportive healthcare facility, the main lobby is an important place to consider because public lobby has the power to comfort visitors whose impressions of the facility both begin and end with the lobby (Bedner, 2013). The user experience in a healthcare facility lobby space is critical because this experience sets expectations for the quality of clinical care (Malkin, 1991, Pangrazio, 2013). However, a limited study has been conducted on users’ wellness experiences in healthcare facility main entry lobbies. Therefore, the purpose of this study is two-fold: 1) to create a user-centered wellness design evaluation criteria for developing and evaluating an existing facility design, or the design of new construction of such facilities; 2) to test and validate a tool for the design of main entry lobby in a healthcare facility using the guidelines and design checklists needed to support a decision-making by the facility designers and administrations. A combination of both quantitative and qualitative research method was used to create a set of wellness design evaluation criteria and a tool for a designing main lobby in a healthcare facility. First, content analysis was conducted on five existing standards and design guidelines of the healthcare facility design. Based on the qualitative research method of content analysis and literature review, five newly developed wellness design goals, including user experience, positive distractions, sense of control, social interaction and safety and security, along with twenty detailed wellness design features were defined. Secondly, the study used an online survey and statistical analysis to determine how participants might perceive the twenty design features. The data was analyzed to identify which design features were important for user’s experience, and how each feature affected their physical well-being, emotional health, and social interaction in a healthcare facility. A total of 299 human subjects who had visited a healthcare facility at least one time during the past 12 months in the United States participated in the online survey. The mean values from the survey results, the importance of the design features, and their impact on physical, emotional, social wellness, were used to create a wellness design evaluation tool. Survey results indicated that infection control, cleanliness and maintenance, and air comfort and freshness were the top three important features of a healthcare facility’s main entry lobby. The survey results also showed the importance of such design features and that the user perceptions of these three wellness categories were correlated. Survey participants’ age group, type of healthcare facility, frequency of visit, and purpose of visit might have had a major impact on the evaluation results. Based on the results, a wellness design evaluation tool with a design checklist was created to support wellness experience of patients, family members, and staffs. The tool was designed to communicate evidence-based and user-centered evaluation criteria among architects, interior designers, and healthcare facility administrations. Although the survey was conducted with a limited number of participants, the study provides some insights with respect to how the general population might perceive the wellness design features in a main entry lobby of a healthcare facility.