In this computational study a two-equation eddy-viscosity model of turbulence is used to predict the development of boundary layers with periodic variation of the free-stream velocity and time-mean adverse pressure gradient. Transport equations are solved for q, the square root of the turbulence kinetic energy and ζ, its dissipation rate. Comparisons with reliable experimental data on such flows verified that the model can satisfactorily reproduce the time-average prime variables as well as their amplitudes. The predicted boundary-layer integral parameters were also found to be in good agreement with comparable data in the literature. Additional comparisons are made with the computed development of the same flow at constant pressure. The effects of the pressure gradient isolated and studied in this way were generally found to be similar to those of nonperiodic flow in similar conditions.