Factors affecting mammary gland immunity and mastitis susceptibility

College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA
Livestock Production Science (Impact Factor: 1.17). 05/2005; 98:89-99. DOI: 10.1016/j.livprodsci.2005.10.017


Dairy cattle are more susceptible to mastitis during the periparturient period. It is well established that the incidence of mastitis with respect to lactation stage are directly related to changes in the composition, magnitude, and efficiency of the mammary gland defense system. There exist numerous genetic, physiological, and environmental factors that can compromise host defense mechanisms during the functional transitions of the mammary gland. For example, physiological stresses associated with rapid differentiation of secretory parenchyma, intense mammary gland growth, and the onset of milk synthesis and secretion are accompanied by a high energy demand and an increased oxygen requirement. This increased oxygen demand augments the production of oxygen-derived reactants, collectively termed reactive oxygen species (ROS). The excessive accumulation of ROS can lead to a condition referred to as oxidant stress that plays a central role in mediating uncontrolled inflammatory responses and causing tissue injury. While the last two decades have seen major progress in understanding the bovine mammary gland defense system and its function in preventing disease, diminished host defenses and increased susceptibility to mastitis continue to be a problem for dairy cattle during transition periods. This paper provides an overview of mammary immunobiology and describes those factors known to influence important mammary gland defenses during the periparturient period.

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Available from: Lorraine M Sordillo
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    • "On the other hand, B lymphocytes are responsible for production of antibodies (immunoglobulins) against specific bacterial pathogens. Among immunoglobulins, IgG 1 , IgG 2 and IgM facilitate phagocytosis by neutrophils and macrophages acting as opsonins, whereas, IgA cause the agglutination of pathogens preventing their spread within the mammary gland (Sordillo, 2005). "
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    • "MG immunity depends on the complex combination and coordination of nonspecific and specific protective elements, including the anatomical features of the gland as well as cellular and humoral defence components [5]. Nevertheless, MG immune defence varies over different stages of lactation in dairy animals and is typically depressed with exposure to stress and around drying-off and parturition, thus increasing susceptibility to mastitis [6] [7]. However, a considerable body of evidence has accumulated suggesting that mastitis is a multifactorial complex, and several management and environmental factors must interact to increase host exposure to mastitis pathogens, reduce the natural resistance of animals to disease, or aid pathogens in gaining entrance to the MG environment to cause infection [2] [4] "
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