Celik I, Gallicchio L, Boyd K, et al. Arsenic in drinking water and lung cancer: a systematic review

Department of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, USA
Environmental Research (Impact Factor: 4.37). 09/2008; 108(1):48-55. DOI: 10.1016/j.envres.2008.04.001


Exposure to inorganic arsenic via drinking water is a growing public health concern. We conducted a systematic review of the literature examining the association between arsenic in drinking water and the risk of lung cancer in humans. Towards this aim, we searched electronic databases for articles published through April 2006. Nine ecological studies, two case–control studies, and six cohort studies were identified. The majority of the studies were conducted in areas of high arsenic exposure (100 μg/L) such as southwestern Taiwan, the Niigata Prefecture, Japan, and Northern Chile. Most of the studies reported markedly higher risks of lung cancer mortality or incidence in high arsenic areas compared to the general population or a low arsenic exposed reference group. The quality assessment showed that, among the studies identified, only four assessed arsenic exposure at the individual level. Further, only one of the ecological studies presented results adjusted for potential confounders other than age; of the cohort and case–control studies, only one-half adjusted for cigarette smoking status in the analysis. Despite these methodologic limitations, the consistent observation of strong, statistically significant associations from different study designs carried out in different regions provide support for a causal association between ingesting drinking water with high concentrations of arsenic and lung cancer. The lung cancer risk at lower exposure concentrations remains uncertain.

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Available from: Ismail Celik, Feb 18, 2014
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    • "Additional non-USA studies include those from Argentina[10,11], Bangladesh[12]and Japan[13]. Previous systematic reviews of lung cancer and ingested arsenic exposure have pointed out the significant associations between lung cancer and high arsenic exposures[14,15]This range was chosen since some publications have suggested that there is a carcinogenic threshold in the 100 µg/L to 200 µg/L range[16,17]. Such a threshold would be consistent with the more recent toxicological/Mode of Action (MOA) findings of arsenic exposure initially inducing a cellular toxicity that leads secondarily to a cellular proliferation. "
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    ABSTRACT: High levels (> 200 μg/L) of inorganic arsenic in drinking water are known to be a cause of human lung cancer, but the evidence at lower levels is uncertain. We have sought the epidemiological studies that have examined the dose-response relationship between arsenic levels in drinking water and the risk of lung cancer over a range that includes both high and low levels of arsenic. Regression analysis, based on six studies identified from an electronic search, examined the relationship between the log of the relative risk and the log of the arsenic exposure over a range of 1–1000 μg/L. The best-fitting continuous meta-regression model was sought and found to be a no-constant linear-quadratic analysis where both the risk and the exposure had been logarithmically transformed. This yielded both a statistically significant positive coefficient for the quadratic term and a statistically significant negative coefficient for the linear term. Sub-analyses by study design yielded results that were similar for both ecological studies and non-ecological studies. Statistically significant X-intercepts consistently found no increased level of risk at approximately 100–150 μg/L arsenic.
    Full-text · Article · Dec 2015 · International Journal of Environmental Research and Public Health
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    • "Arsenic in the present times has become one of the most important global environmental toxicant which has caused health hazards to human population through its contamination in ground drinking water with inorganic arsenic [1]. "
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    ABSTRACT: Arsenic is present in the environment and human all over the world are exposed to small amounts, mostly through food, water, and air. In the developing countries like Bangladesh and India, the high prevalence of contamination, the isolation and poverty of the rural population and the high cost and complexity of arsenic removal systems have imposed a programmatic and policy challenge on an unprecedented scale. Although in India, Arsenic poisoning in ground water in Gangetic basin especially the districts adjoining the river Ganges right from Eastern Uttar Pradesh, Bihar to West Bengal is the major problem of concern. Due to which, major health related problems are arising in the population.To combat the present problem, a pre-clinical study was done on Charles foster rats and sodium arsenite at the dose of 8 mg Kg-1 body weight per day was administered to these rats for 60 days and upon these arsenic pretreated rats, novel plant extracts of Withania somnifera and Pteris longifolia were administered for 45 days to study the antidote effects of these plant extracts. These plants not only eliminated the toxic effects of arsenic but also reversed the normal physiological activity in the animal. Thus, the present study concludes that these novel plants possesses the best bioremedial impact against arsenic induced toxicity.
    Full-text · Article · Feb 2015
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    • "Arsenic is a carcinogenic element known for its poisonous characteristics which is regarded as one of the most critical environmental threats of the world for millions of people (Celik et al., 2008; Ravenscroft et al., 2009). Arsenic is a naturally existing element and its presence in food proves that it is usually accumulated from the environment (Roychowdhury et al., 2002). "
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    ABSTRACT: Yabanli, M., S. Tay & D. Giannetto, 2015. Human health risk assessment from arsenic exposure after sea bream (Sparus aurata) consumption in Aegean region, Turkey. Bulg. J. Vet. Med. (online first). The aim of the present study was to determine the amount of arsenic in the muscular tissues of wild sea breams, sea breams cultured in soil ponds and sea breams cultured in offshore marine cage systems in the Aegean Region of Turkey. Then an estimated daily intake (EDI) and target hazard quotient (THQ) based risk assessment by sea bream consumption in terms of arsenic was performed for both children and adults. The arsenic concentrations in the muscular tissues of fish were detected by inductively coupled plasma-mass spectrometry method after digestion by microwave wet burning. According to the results obtained, the highest average arsenic concentration was found in sea bream cultured in soil pond while the lowest was determined in off shore marine cultured sea bream. The arsenic concentrations determined in all fish groups were found out to be below 1 –1 wet weight which is the international legal limit. Also the EDI values determined for children and adults were lower than 0.30 µg/kg/day, the oral reference doses (RfDo) value for arsenic and THQ value was found out to be lower than the value assessed as potentially carcinogenic. Summarising, the results of this study do not underline any potential risk in term of arsenic deriving from consumption of sea bream cultured and caught in Aegean Sea.
    Full-text · Article · Jan 2015 · Bulgarian Journal of Veterinary Medicine
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