In-vivo Antidiabetic activity of Alcoholic and Aqueous Extract of Nymphaea lotus in Rat Model

Inventi Rapid: Ethnopharmacology 03/2011; 2011(3).


The hypoglycemic activity of the ethanolic extract was evaluated in alloxan induced
diabetic rats by single dose of 100mg/kg body weight. Antihyperglycemic activity of the
extract was also evaluated at the same dose levels in alloxan monohydrate (80mg/kg s.c.)
induced diabetic rats during a 15 days treatment period. Glibenclamide (4.5mg/kg) was used
as the reference drug. Fasting blood glucose and sarum parameters triglycerides, total
cholesterol, HDL cholesterol levels were measured acute oral toxicity of theNymphaea
lotus rhizome extract was carried out in swiss albino mice. In diabetic rats, ethanolic extract
showed a significant (P<0.05) decreased the blood glucose level in a dose dependent manner
during the 15 days of the treatment period. In the acute oral toxicity study, Nymphaea
lotus showed no mortality. The present investigation shows that Nymphaea lotus rhizome has
potential anti diabetic effects.

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Available from: Arshed Iqbal Dar, Mar 14, 2015
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