... Transgender persons-individuals who identify with a gender that differs from their sex assigned at birth-are more likely than cisgender persons to experience a variety of social and economic stressors, including housing instability and economic hardship (Balsam, Rothblum, & Beauchaine, 2005;Blosnich et al., 2013;Blosnich, Marsiglio, et al., 2017;Brown & Jones, 2016;Grant et al., 2010;Hughes, Johnson, & Wilsnack, 2001;Lehavot et al., 2016;Shipherd, Darling, Klap, Rose, & Yano, 2018;Stotzer, 2009), likely resulting from substantial exposure to transphobic discrimination and violence (Bradford, Reisner, Honnold, & Xavier, 2013;James et al., 2016;Lombardi, Wilchins, Priesing, & Malouf, 2002;White Hughto, Reisner, & Pachankis, 2015;Wolfe et al., 2021). The Minority Stress Model posits that discrimination, violence, rejection, and internalized stigma (e.g., internalized transphobia) (Meyer, 2003) negatively affect a person's resilience and ability to cope with stress (Hendricks & Testa, 2012), thereby increasing risk for adverse health outcomes, including substance use disorders (SUDs) (Hatzenbuehler, 2009;Labouvie & Bates, 2002;Meyer, 1995Meyer, , 2003Tartaglia & Bergagna, 2020). ...