Thrombotic microangiopathy and fibrinolysis after hump-nosed viper envenomation

District General Hospital, Polonnaruwa, Sri Lanka. .
Ceylon Medical Journal 03/2012; 57(1):45-6. DOI: 10.4038/cmj.v57i1.4204
Source: PubMed

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    • "Microangiopathic hemolytic anemia with thrombocytopenia, coagulopathy, fibrinolysis, thrombocytopenia or spontaneous systemic hemorrhage, and a case of hemolytic uremic syndrome, have been reported with HNV bite [5,6,26-28]. Consumptive coagulopathy has been purported to be the mechanism for these manifestations in some cases [27,28]. Isbister [29] described this venom-induced coagulopathy as constituting the commonest coagulopathy associated with snake envenoming. "
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    ABSTRACT: Hump-nosed viper bites are common in the Indian subcontinent. In the past, hump-nosed vipers (Hypnale species) were considered moderately venomous snakes whose bites result mainly in local envenoming. However, a variety of severe local effects, hemostatic dysfunction, microangiopathic hemolysis, kidney injury and death have been reported following envenoming by Hypnale species. We systematically reviewed the medical literature on the epidemiology, toxin profile, diagnosis, and clinical, laboratory and postmortem features of hump-nosed viper envenoming, and highlight the need for development of an effective antivenom.
    Full-text · Article · Jun 2014 · Journal of Venomous Animals and Toxins including Tropical Diseases