Anterior cingulate activation relates to local cortical thickness

Jane and Terry Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, USA.
Neuroreport (Impact Factor: 1.52). 03/2012; 23(7):420-4. DOI: 10.1097/WNR.0b013e3283525a95
Source: PubMed


Few studies have examined the relationship between local anatomic thickness of the cortex and the activation signals arising from it. Using structural and functional MRI, we examined whether a relationship exists between cortical thickness and brain activation. Twenty-eight participants were asked to perform the Go/NoGo response inhibition task known to activate the anterior cingulate and the prefrontal cortex. Structural data of the same regions were simultaneously collected. We hypothesized that cortical thickness in these brain regions would positively correlate with brain activation. Data from the structural MRI were aligned with those of functional MRI activation. There was a positive linear correlation between cortical thickness and activation during response inhibition in the right anterior cingulate cortex (Brodmann's Area 24). No significant thickness-activation correlations were found in the prefrontal cortex. Correlations between cortical thickness and activation may occur only in certain brain regions.

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    • "Ilg and colleagues (2008) for instance showed that healthy individuals, trained to practice on a mirror reading task 15 min a day for 2 weeks had a significant GMV increase in the right dorsolateral occipital cortex, accompanied by modifications of the functional activity within the same region but also extending to the superior parietal areas (see also Haier et al. 2009; Hegarty et al. 2012; Schmidt- Wilcke et al. 2010 for corresponding findings). The relationship between training-induced change in hemodynamic responses and grey and WM structures remains, however, largely unexplored. "
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