Neuronal functions of ESCRTs

Department of Biotechnology, College of Life Science and Nano Technology, Hannam University, Dajeon 305-811, Korea.
Experimental neurobiology 03/2012; 21(1):9-15. DOI: 10.5607/en.2012.21.1.9
Source: PubMed


The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodegeneration. However, it remains largely elusive how ESCRTs act in post-mitotic neurons, a highly specialized cell type that requires dynamic changes in neuronal structures and signaling for proper function. This review focuses on our current understandings of the functions of ESCRTs in neuronal morphology, synaptic plasticity, and neurodegenerative diseases.

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    • "We also observed that two members of electron transport proteins (ATP5D, NDUFS3) were enriched in the neural cells. The association of vacuolar protein sorting (vps) proteins with neuronal morphology, synaptic plasticity, and neurodegenerative diseases has been described previously which may suggest their possible contribution in neural differentiation (for review see [40]). Adp ribosylation factor-like protein 2 (Arl2) is a monomeric G protein which could interact with tubulin-folding cofactors and protects the tubulins from destruction [41] and has a role in the survival of neural progenitors differentiated from hESC [42] "
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    Full-text · Article · Feb 2014 · Journal of proteomics
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    • "After completion of autophagosome formation, autophagosomes can fuse with endosomes or lysosomes. Although it is unclear how exactly autophagosomes fuse with lysosomes, their fusion is known to require several proteins such as LAMP2, the Rubicon-UVRAG complex, SNAREs (soluble N-ethylmalemide sensitive factor attachment protein receptor), HOPS (homotypic fusion and protein sorting), Rab (Ras [rat sarcoma] like in rat brain), ESCRT (Endosormal sorting complex required for transport), and LC3 [4, 10, 11]. Once the autophagosome fuses with lysosomes, cytosolic components are degraded by hydrolases and lipases. "
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