Cryptococcal osteomyelitis of the scapula and rib in an immunocompetent patient

* Department of Infectious Diseases, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University , Shanghai.
Medical mycology: official publication of the International Society for Human and Animal Mycology (Impact Factor: 2.34). 03/2012; 50(7):751-5. DOI: 10.3109/13693786.2012.670277
Source: PubMed


Cryptococcal osteomyelitis is extremely rare and almost always occurs in immunocompromised patients. We describe a case of
osteomyelitis due to Cryptococcus neoformans involving both scapula and rib in an immunocompetent and previously healthy patient. The patient received treatment with
amphotericin B deoxycholate and flucytosine for 4 weeks, followed by oral fluconazole 400 mg per day for 8 weeks and 200 mg
per day for 9 months. The 12-month course of antifungal therapy resulted in complete clinical recovery and undetectable serum
cryptococcal antigen. Cryptococcal osteomyelitis should be suspected in any immunocompetent patient with osteolytic lesions
on radiological images.

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