Secreted miRNAs suppress atherogenesis

Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11-125 Translational Research Center, Philadelphia, Philadelphia 19104-5156, USA.
Nature Cell Biology (Impact Factor: 19.68). 02/2012; 14(3):233-5. DOI: 10.1038/ncb2452
Source: PubMed


Endothelial-vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.

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    • "producing cells (Chairoungdua et al., 2010; Verweij et al., 2011) and may also be of importance in vivo (Al-Nedawi et al., 2009; Peinado et al., 2012). However, it does appear that microRNAs may be specifically transported into cells for specialized functions while the target cells seems to lack these microRNAs (Rader and Parmacek, 2012). "
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