Typical carcinoid arising in mature teratoma of anterior mediastinum

Article (PDF Available)inAsian cardiovascular & thoracic annals 20(1):80-2 · February 2012with21 Reads
DOI: 10.1177/0218492311428185 · Source: PubMed
Teratoma is the second most common mediastinal neoplasm, but malignant transformation in mature teratomas is uncommon at both gonadal and extragonadal sites. A 35-year-old woman presented with an anterior mediastinal mass. Computed tomography suggested a teratoma. Meticulous pathological examination helped in detecting a neuroendocrine neoplasm (carcinoid) within the mature teratoma. Malignant transformation in a teratoma is difficult to diagnose on clinical and radiological assessment; histopathology is essential to detect the malignant nature of these neoplasms.

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Available from: Niraj Kumari, Sep 24, 2015
    • "TMT denotes a GCT containing a malignant somatic element, like sarcoma, carcinoma or both, which occurs infrequently in around 7% of all mediastinal teratomas [4, 5]. TMT has been divided into two clinical and pathologic conditions: TMT induced by chemotherapy or irradiation and naturally occurring TMT [6]. The former type accounts for nearly all cases of TMT, while the latter type has been reported only rarely. "
    [Show abstract] [Hide abstract] ABSTRACT: Presented herein is a case of mediastinal mature teratoma with adenocarcinomatous transformation predominantly composed of mucinous adenocarcinoma in a 25-year-old man. Disease progressed despite application of surgical removal, adjuvant radio- and chemotherapy. Further immunohistochemical stains indicated a gastrointestinal origin of the tumor. Consequently chemotherapy according to the FOLFIRI regimen was applied that resulted in good response. To our knowledge, this is the first report of a clinical remission from chemotherapy with the FOLFIRI regimen after comprehensive initial treatment with surgery, radio- and chemotherapy for a patient with teratoma with malignant transformation, highlighting the importance of choosing an appropriate chemotherapy regimen.
    Article · May 2016
    • "But, carcinoid tumors are usually chemoresistant, and radiotherapy has only a palliative role in local control. Therefore, in cases with carcinoid, it is advocated that patients with low-volume metastatic disease be kept under observation, whereas those who have carcinoid syndrome should receive long-term somatostatin analogs [9]. In a study of a series of patients with mediastinal teratoma with malignant transformation, 3 patients were noted to have only 4-6 months of treatment response, despite comprehensive treatment of surgery, chemotherapy, or radiation [12]. "
    [Show abstract] [Hide abstract] ABSTRACT: Germ cell tumors constitute 10% to 15% of anterior mediastinal neoplasms. Of these, mature teratoma is the most common. Somatic malignant transformation in mature teratoma is a very rare phenomenon. In the anterior mediastinum, few cases of malignant transformation in the form of carcinoma, sarcoma, or neuroendocrine tumors have been described. We present the case of a mature mediastinal teratoma in a 24-year-old female, diagnosed on computed tomography, where both carcinoid tumor and adenocarcinoma were seen. To the best of our knowledge, this is the first report of such a case. Malignant transformation in a mature teratoma confers a significantly worse prognosis and is difficult to diagnose only on clinical and radiological evaluation. As these lesions are so rare, the treatment options for these lesions are also not clearly defined. Extensive sampling and careful microscopic examination are needed when teratomas are submitted for pathological evaluation.
    Article · Apr 2015
  • [Show abstract] [Hide abstract] ABSTRACT: Background. A carcinoid arising from a mature cystic teratoma of the mediastinum is rare. Case. A 38-year-old man was admitted to our hospital for evaluation of an abnormal shadow on a chest radiograph. Chest CT scan and MRI showed a well-defined mass with calcification and heterogeneous components in the right anterior mediastinum. Video-assisted thoracic surgery was performed to resect the tumor, which was suspected to be a mediastinal teratoma. The histopathological diagnosis was a carcinoid arising from a mature cystic teratoma of the mediastinum. Conclusion. We report a rare case of a carcinoid arising from a mature cystic teratoma of the mediastinum.
    Article · Dec 2012
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