SiteComp: A server for ligand binding site analysis in protein structures

Department of Structural and Chemical Biology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Bioinformatics (Impact Factor: 4.98). 02/2012; 28(8):1172-3. DOI: 10.1093/bioinformatics/bts095
Source: PubMed


MOTIVATION: Computational characterization of ligand-binding sites in proteins provides preliminary information for functional annotation, protein design and ligand optimization. SiteComp implements binding site analysis for comparison of binding sites, evaluation of residue contribution to binding sites and identification of sub-sites with distinct molecular interaction properties. Availability and implementation: The SiteComp server and tutorials are freely available at

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Available from: Yingjie Lin, Jun 19, 2014
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    • "The pre-calculated results of ProBiS analysis are available via ProBiS-database [64] as a repository of structurally similar binding sites. SiteComp [62] characterizes protein binding site using molecular interaction fields based descriptors. The server evaluates differences in similar binding sites, identification of sub-sites and residue contributions in ligand binding. "
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