Article

Small RNA in the nucleus: The RNA-chromatin ping-pong

California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA.
Current opinion in genetics & development (Impact Factor: 7.57). 02/2012; 22(2):164-71. DOI: 10.1016/j.gde.2012.01.002
Source: PubMed

ABSTRACT

Eukaryotes use several classes of small RNA molecules to guide diverse protein machineries to target messenger RNA. The role of small RNA in post-transcriptional regulation of mRNA stability and translation is now well established. Small RNAs can also guide sequence-specific modification of chromatin structure and thus contribute to establishment and maintenance of distinct chromatin domains. In this review we summarize the model for the inter-dependent interaction between small RNA and chromatin that has emerged from studies on fission yeast and plants. We focus on recent results that link a distinct class of small RNAs, the piRNAs, to chromatin regulation in animals.

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Available from: Katalin Fejes Toth
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