Ventral striatal prediction error signaling is associated with dopamine synthesis capacity and fluid intelligence

Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Germany.
Human Brain Mapping (Impact Factor: 5.97). 06/2013; 34(6). DOI: 10.1002/hbm.22000
Source: PubMed


Fluid intelligence represents the capacity for flexible problem solving and rapid behavioral adaptation. Rewards drive flexible behavioral adaptation, in part via a teaching signal expressed as reward prediction errors in the ventral striatum, which has been associated with phasic dopamine release in animal studies. We examined a sample of 28 healthy male adults using multimodal imaging and biological parametric mapping with (1) functional magnetic resonance imaging during a reversal learning task and (2) in a subsample of 17 subjects also with positron emission tomography using 6-[(18) F]fluoro-L-DOPA to assess dopamine synthesis capacity. Fluid intelligence was measured using a battery of nine standard neuropsychological tests. Ventral striatal BOLD correlates of reward prediction errors were positively correlated with fluid intelligence and, in the right ventral striatum, also inversely correlated with dopamine synthesis capacity (FDOPA K inapp). When exploring aspects of fluid intelligence, we observed that prediction error signaling correlates with complex attention and reasoning. These findings indicate that individual differences in the capacity for flexible problem solving relate to ventral striatal activation during reward-related learning, which in turn proved to be inversely associated with ventral striatal dopamine synthesis capacity. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc.

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Available from: Anthony Grace, Jan 07, 2014
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    • "The functional differentiation of specific striatal areas for cognition has been suggested before, for instance distinguishing between ventral (learning) and dorsal (response execution) regions [Humphries and Prescott, 2010; Mac- Donald et al., 2011; Schlagenhauf et al., 2013; Voorn et al., 2004; Wickens et al., 2007]. Here we report converging morphological evidence, given that we observed anteroventral , but virtually no caudal and dorsal areas of the basal ganglia, to be significantly relevant for cognitive performance. "
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    Full-text · Article · May 2014 · Human Brain Mapping
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    • "This may point to a common biological alteration even in a heterogeneous population of schizophrenia patients. Theoretical work (Heinz, 2002; Kapur, 2003), and previous work in our group (Schlagenhauf et al., 2013), support the idea that VS hypoactivation in schizophrenia may be related to elevated levels of dopamine . Indeed, prediction error BOLD correlates are inversely correlated with dopamine synthesis capacity (measured by FDOPA PET) in the ventral striatum (Schlagenhauf et al., 2012). "
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